Cmax is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administered and before the administration of a second dose. It is a standard measurement in pharmacokinetics. See more Cmax is the opposite of Cmin, which is the minimum (or trough) concentration that a drug achieves after dosing. The related pharmacokinetic parameter tmax is the time at which the Cmax is observed. After an … See more • Cmean (pharmacology) • Area under the curve (pharmacokinetics) See more WebFeb 24, 2014 · Cmax,ss of BEVZ92 and Avastin® [ Time Frame: Cmax, ss: 0 to 336 hours post-dose after the administration of Cycle 7 infusion (Week 13) ] ... Ctrough,sd of BEVZ92 and Avastin® [ Time Frame: Ctrough, sd: 0 to 336 hours after start of the first infusion. ] Secondary PK endpoints included the Ctrough calculated at Cycle 1 (Ctrough,sd )
Ctrough English to French Medical: Pharmaceuticals - ProZ.com
WebGenerate concentration-time profiles from linear pharmacokinetic (PK) systems, possibly with first-order absorption or zero-order infusion, possibly with one or more peripheral compartments, and possibly under steady-state conditions. Single or multiple doses may be specified. Secondary (derived) PK parameters (e.g. Cmax, Ctrough, AUC, Tmax, half … WebFeb 24, 2014 · Drug: Bevacizumab biosimilar (BEVZ92) Active ingredient Bevacizumab 25 mg/mL (strength = 100 mg/4 mL). 30-minute* IV infusion (5 mg/kg) every 2 weeks, prior … iottie ion wireless
多次给药PK研究中，Cmin和Ctrough的定义有什么区别？
WebOct 14, 2024 · Plasma concentrations of mirdametinib and BGB-3245 will be measured to evaluate systemic exposures (AUC, Cmax, Ctrough, and other PK parameters as data allow). Eligibility Criteria. Go to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More … WebIf using bolus IV Cmax (or extrapolated C0) relate to volume of distribiution of the central compatrtment and not clearance. If using IV infusion, then Cmax also depends on … WebPeak drug concentrations ( Cmax) and inter-dose area under the concentration-time curve (AUC) are considered to be better predictors of efficacy and/or toxicity than C0. … on which day is thanksgiving day