WebInterstrand DNA crosslinks (ICLs) are lesions that are a covalent linkage between opposite strands of double-stranded DNA. They are formed in the presence of bi-functional alkylating agents [1–4]. Organisms are exposed to bifunctional alkylating agents, also called ICL-causing agents, as a result of endogenous metabolic processes as WebJul 1, 2002 · The formation of crosslinks between the 2 strands of DNA, interstrand crosslinking, is considered to be a critical event, and there is clear evidence that their formation and subsequent persistence correlates with in vitro cytotoxicity.10,11 In vitro resistance to nitrogen mustards has been associated with defects in drug transport …
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