WebTGF-a is expressed by villus enterocytes and may have an important role in mucosal healing. The Trefoil peptides (pS2, spasmolytic polypeptide, intestinal trefoil factor) are protease resistant molecules secreted by mucin cells throughout the gut, with a role in mucosal healing. The TGF-b family inhibit cell proliferation, ... http://www.cancerindex.org/geneweb/TFF2.htm
Trefoil Factor 3 is Highly Predictive of Complete Mucosal Healing ...
WebTrefoil factors are peptides synthesized in and secreted by the mucin-producing cells of epithelial ... pancreatic secretions. 180,181 The expression of EGFR ligands is upregulated … WebTrefoil factor 1 (TFF1) plays a crucial role in mucosal defense and healing, and evidence suggests that GATA-5 mediated its regulation. Gastric cancer is a multiple-step process triggered by Helicobacter pylori and is characterized by accumulation of molecular and epigenetic alteration. marketivate.com
Human Gene TFF1 (ENST00000291527.3) from GENCODE V39
WebDescription: Homo sapiens growth factor receptor bound protein 2 (GRB2), transcript variant 1, mRNA. (from RefSeq NM_002086) RefSeq Summary (NM_002086): The protein … WebEpithelial continuity depends on a family of small, yet abundant, secreted proteins - the trefoil factors (TFFs). TFFs protect mucous epithelia from a range of insults and … WebNov 29, 2024 · Structural, mutagenic and biophysical data reveal that TFF activity is dependent on the glycosylation state of mucosal glycoproteins and alludes to a lectin function for trefoil domains in other human proteins. The mucosal epithelium secretes a host of protective disulfide-rich peptides, including the trefoil factors (TFFs). The TFFs … navid filsoof